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Article

Whole-genome genotyping with the single-base extension assay.

Nature methods - 1 Jan 2006

Steemers Frank J, Chang Weihua, Lee Grace, Barker David L, Shen Richard, Gunderson Kevin L

Abstract excerpt

We describe an efficient, accurate and robust whole-genome genotyping (WGG) assay based on a two-color, single-base extension (SBE), single-nucleotide polymorphism (SNP)-scoring step. We report genotyping results for biallelic International HapMap quality control (QC) SNPs using a single probe per locus. We show scalability, throughput and accuracy of the system by resequencing homozygous loci from our 100k...

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PMID: 16369550
DOI: 10.1038/nmeth842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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