Article
A genotyping system capable of simultaneously analyzing >1000 single nucleotide polymorphisms in a haploid genome.
Genome research - 1 Feb 2005
Wang Hui-Yun, Luo Minjie, Tereshchenko Irina V, Frikker Danielle M, Cui Xiangfeng, Li James Y, Hu Guohong, Chu Yi, Azaro Marco A, Lin Yong, Shen Li, Yang Qifeng, Kambouris Manousos E, Gao Richeng, Shih Weichung, Li Honghua
Abstract excerpt
A high-throughput genotyping system for scoring single nucleotide polymorphisms (SNPs) has been developed. With this system, >1000 SNPs can be analyzed in a single assay, with a sensitivity that allows the use of single haploid cells as starting material. In the multiplex polymorphic sequence amplification step, instead of attaching universal sequences to the amplicons, primers that are unlikely to have...
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