Article
Large-scale validation of single nucleotide polymorphisms in gene regions.
Genome research - 1 Aug 2004
Nelson Matthew R, Marnellos George, Kammerer Stefan, Hoyal Carolyn R, Shi Michael M, Cantor Charles R, Braun Andreas
Abstract excerpt
Genome-wide association studies using large numbers of bi-allelic single nucleotide polymorphisms (SNPs) have been proposed as a potentially powerful method for identifying genes involved in common diseases. To assemble a SNP collection appropriate for large-scale association, we designed assays for 226,099 publicly available SNPs located primarily within known and predicted gene regions. Allele frequencies were...
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