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Article

SBE-TAGS: an array-based method for efficient single-nucleotide polymorphism genotyping.

Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 2000

Hirschhorn J N, Sklar P, Lindblad-Toh K, Lim Y M, Ruiz-Gutierrez M, Bolk S, Langhorst B, Schaffner S, Winchester E, Lander E S

Abstract excerpt

Generating human single-nucleotide polymorphisms (SNPs) is no longer a rate-limiting step for genetic studies of disease. The number of SNPs in public databases already exceeds 200,000, and the total is expected to exceed 1,000,000 within a year. Rather, progress is limited by the inability to genotype large numbers of SNPs. Current genotyping methods are suitable for studying individual loci or at most a handful...

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PMID: 11035790
DOI: 10.1073/pnas.210394597
PMCID: PMC17312

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