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Article

Differential regulation of two isoforms of the glial glutamate transporter EAAT2 by DLG1 and CaMKII.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Apr 2015

Underhill Suzanne M, Wheeler David S, Amara Susan G

Abstract excerpt

The gene for EAAT2, the major astrocytic glutamate transporter, generates two carrier isoforms (EAAT2a and EAAT2b) that vary at their C termini as a consequence of alternative RNA splicing. The EAAT2b cytoplasmic C terminus contains a postsynaptic density-95/Discs large/zona occludens-1 (PDZ) ligand, which is absent in EAAT2a. To understand how the distinct C termini might affect transporter trafficking and...

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Share to Astrocytes
Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Excitatory Amino Acid Transporter 2

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Source

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Identifiers

PMID: 25834051
DOI: 10.1523/JNEUROSCI.4365-14.2015
PMCID: PMC4380999

Genes

DLG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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