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Article

Disruption of an EAAT-Mediated Chloride Channel in a Drosophila Model of Ataxia.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Jul 2016

Parinejad Neda, Peco Emilie, Ferreira Tiago, Stacey Stephanie M, van Meyel Donald J

Abstract excerpt

UNLABELLED: Patients with Type 6 episodic ataxia (EA6) have mutations of the excitatory amino acid transporter EAAT1 (also known as GLAST), but the underlying pathophysiological mechanism for EA6 is not known. EAAT1 is a glutamate transporter expressed by astrocytes and other glia, and it serves dual function as an anion channel. One EA6-associated mutation is a P>R substitution (EAAT1(P>R)) that in transfected...

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Identifiers

PMID: 27445142
DOI: 10.1523/JNEUROSCI.0197-16.2016
PMCID: PMC6705562

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Source receipt: pubmed, retrieved 7 Sept 2026.

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