A human recombinant haemoglobin designed for use as a blood substitute.

doi:10.1038/356258a0

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A human recombinant haemoglobin designed for use as a blood substitute.

Nature - 19 Mar 1992

Looker D, Abbott-Brown D, Cozart P, Durfee S, Hoffman S, Mathews A J, Miller-Roehrich J, Shoemaker S, Trimble S, Fermi G

Abstract excerpt

The need to develop a blood substitute is now urgent because of the increasing concern over blood-transmitted viral and bacterial pathogens. Cell-free haemoglobin solutions and human haemoglobin synthesized in Escherichia coli and Saccharomyces cerevisiae have been investigated as potential oxyge...

Topics

Animals
Blood Substitutes
Crystallization
Escherichia coli
Globins
Half-Life
Hemoglobins
Humans
Kidney Diseases
Macromolecular Substances
Molecular Structure
Mutation
Oxygen
Rats
Rats, Inbred Strains
Recombinant Fusion Proteins

Source

Open in PubMed

Identifiers

PMID: 1552945
DOI: 10.1038/356258a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1552945-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics