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Article

A human recombinant haemoglobin designed for use as a blood substitute.

Nature - 19 Mar 1992

Looker D, Abbott-Brown D, Cozart P, Durfee S, Hoffman S, Mathews A J, Miller-Roehrich J, Shoemaker S, Trimble S, Fermi G

Abstract excerpt

The need to develop a blood substitute is now urgent because of the increasing concern over blood-transmitted viral and bacterial pathogens. Cell-free haemoglobin solutions and human haemoglobin synthesized in Escherichia coli and Saccharomyces cerevisiae have been investigated as potential oxygen-carrying substitutes for red blood cells. But these haemoglobins cannot be used as a blood substitute because (1) the...

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PMID: 1552945
DOI: 10.1038/356258a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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