Article
Novel Redox Active Tyrosine Mutations Enhance the Regeneration of Functional Oxyhemoglobin from Methemoglobin: Implications for Design of Blood Substitutes.
Advances in experimental medicine and biology - 1 Jan 2018
Silkstone G G A, Simons M, Rajagopal B S, Shaik T, Reeder B J, Cooper C E
Abstract excerpt
Heme mediated oxidative toxicity has been linked to adverse side effects in Hemoglobin Based Oxygen Carriers (HBOC), initiated by reactive ferryl (FeIV) iron and globin based free radical species. We recently showed that the addition of a redox active tyrosine residue in the beta subunit (βF41Y) of recombinant hemoglobin had the capability to decrease lipid peroxidation by facilitating the reduction of FeIV iron...
Topics
- Blood Substitutes
- Drug Design
- Humans
- Methemoglobin
- Mutation
- Oxidation-Reduction
- Oxyhemoglobins
- Tyrosine