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Article

The βLys66Tyr Variant of Human Hemoglobin as a Component of a Blood Substitute.

Advances in experimental medicine and biology - 1 Jan 2016

Silkstone R S, Silkstone G, Baath J A, Rajagopal B, Nicholls P, Reeder B J, Ronda L, Bulow L, Cooper C E

Abstract excerpt

It has been proposed that introducing tyrosine residues into human hemoglobin (e.g. βPhe41Tyr) may be able to reduce the toxicity of the ferryl heme species in extracellular hemoglobin-based oxygen carriers (HBOC) by facilitating long-range electron transfer from endogenous and exogenous antioxidants. Surface-exposed residues lying close to the solvent exposed heme edge may be good candidates for mutations. We...

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Identifiers

PMID: 26782245
DOI: 10.1007/978-1-4939-3023-4_57

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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