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Article

Engineering tyrosine electron transfer pathways decreases oxidative toxicity in hemoglobin: implications for blood substitute design.

The Biochemical journal - 1 Oct 2016

Silkstone Gary G A, Silkstone Rebecca S, Wilson Michael T, Simons Michelle, Bülow Leif, Kallberg Kristian, Ratanasopa Khuanpiroon, Ronda Luca, Mozzarelli Andrea, Reeder Brandon J, Cooper Chris E

Abstract excerpt

Hemoglobin (Hb)-based oxygen carriers (HBOC) have been engineered to replace or augment the oxygen-carrying capacity of erythrocytes. However, clinical results have generally been disappointing due to adverse side effects linked to intrinsic heme-mediated oxidative toxicity and nitric oxide (NO) scavenging. Redox-active tyrosine residues can facilitate electron transfer between endogenous antioxidants and...

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Identifiers

PMID: 27470146
DOI: 10.1042/BCJ20160243
PMCID: PMC5095908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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