Additive effects of beta chain mutations in low oxygen affinity hemoglobin betaF41Y,K66T.

doi:10.1074/jbc.274.36.25550

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Article

Additive effects of beta chain mutations in low oxygen affinity hemoglobin betaF41Y,K66T.

The Journal of biological chemistry - 3 Sept 1999

Baudin-Creuza V, Vasseur-Godbillon C, Griffon N, Kister J, Kiger L, Poyart C, Marden M C, Pagnier J

Abstract excerpt

In order to decrease significantly the oxygen affinity of human hemoglobin, we have associated the mutation betaF41Y with another point mutation also known to decrease the oxygen affinity of Hb. We have synthesized a recombinant Hb (rHb) with two mutations in the beta chains: rHb betaF41Y,K66T. I...

Topics

Escherichia coli
Globins
Hemoglobins
Humans
Mutation
Oxygen
Protein Conformation
Recombinant Proteins

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