Article
The glycosphingolipid globotriaosylceramide in the metastatic transformation of colon cancer.
Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2005
Kovbasnjuk Olga, Mourtazina Rakhilya, Baibakov Boris, Wang Thomas, Elowsky Christian, Choti Michael A, Kane Anne, Donowitz Mark
Abstract excerpt
The most devastating aspect of cancer is the emergence of metastases. Thus, identification of potentially metastatic cells among a tumor cell population and the underlying molecular changes that switch cells to a metastatic state are among the most important issues in cancer biology. Here we show that, although normal human colonic epithelial cells lack the glycosphingolipid globotriaosylceramide (Gb(3)), this...
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