Article
Reduced susceptibility to colitis-associated colon carcinogenesis in mice lacking plasma membrane-associated sialidase.
PloS one - 1 Jan 2012
Yamaguchi Kazunori, Shiozaki Kazuhiro, Moriya Setsuko, Koseki Koichi, Wada Tadashi, Tateno Hiroo, Sato Ikuro, Asano Masahide, Iwakura Yoichiro, Miyagi Taeko
Abstract excerpt
Sialic acids are acidic monosaccharides that bind to the sugar chains of glycoconjugates and change their conformation, intermolecular interactions, and/or half-life. Thus, sialidases are believed to modulate the function of sialoglycoconjugates by desialylation. We previously reported that the m...
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