Article
Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems.
Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2005
Constância Miguel, Angiolini Emily, Sandovici Ionel, Smith Paul, Smith Rachel, Kelsey Gavin, Dean Wendy, Ferguson-Smith Anne, Sibley Colin P, Reik Wolf, Fowden Abigail
Abstract excerpt
The mammalian fetus is unique in its dependence during gestation on the supply of maternal nutrients through the placenta. Maternal supply and fetal demand for nutrients need to be fine tuned for healthy growth and development of the fetus along its genetic trajectory. An altered balance between supply and demand can lead to deviations from this trajectory with long-term consequences for health. We have...
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