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Article

Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene

1 Jul 2023

Abstract excerpt

Maternal-offspring interactions in mammals involve both cooperation and conflict. The fetus has evolved ways to manipulate maternal physiology to enhance placental nutrient transfer, but the mechanisms involved remain unclear. The imprinted Igf2 gene is highly expressed in murine placental endocrine cells. Here, we show that Igf2 deletion in these cells impairs placental endocrine signaling to the mother, without...

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Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting
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Identifiers

PMID: 37437545
DOI: 10.1016/j.cmet.2023.06.007

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