Article
Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2011
Angiolini Emily, Coan Phillip M, Sandovici Ionel, Iwajomo O H, Peck Gerrard, Burton Graham J, Sibley Colin P, Reik Wolf, Fowden Abigail L, Constância Miguel
Abstract excerpt
The healthy development of the fetus depends on an optimal balance between fetal genetic drive for growth and the maternal ability to provide nutrients through the placenta. Nothing is known about fetal-placental signaling in response to increased fetal demand in the situation of overgrowth. Here, we examined this question using the H19(Δ13) mouse model, shown previously to result in elevated levels of Igf2....
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