Article
Imprinted genes and the epigenetic regulation of placental phenotype.
Progress in biophysics and molecular biology - 1 Jul 2011
Fowden A L, Coan P M, Angiolini E, Burton G J, Constancia M
Abstract excerpt
Imprinted genes are expressed in a parent-of-origin manner by epigenetic modifications that silence either the paternal or maternal allele. They are widely expressed in fetal and placental tissues and are essential for normal placental development. In general, paternally expressed genes enhance feto-placental growth while maternally expressed genes limit conceptus growth, consistent with the hypothesis that...
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