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Article

Placental-specific IGF-II is a major modulator of placental and fetal growth.

Nature - 27 Jun 2002

Constância Miguel, Hemberger Myriam, Hughes Jennifer, Dean Wendy, Ferguson-Smith Anne, Fundele Reinald, Stewart Francesca, Kelsey Gavin, Fowden Abigail, Sibley Colin, Reik Wolf

Abstract excerpt

Imprinted genes in mammals are expressed from only one of the parental chromosomes, and are crucial for placental development and fetal growth. The insulin-like growth factor II gene (Igf2) is paternally expressed in the fetus and placenta. Here we show that deletion from the Igf2 gene of a trans...

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Identifiers

PMID: 12087403
DOI: 10.1038/nature00819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12087403-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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