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Article

AIB1 polymorphisms predict aggressive ovarian cancer phenotype.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2005

Li Andrew J, Lerner Dimitry L, Gapuzan Maria-Emily R, Karlan Beth Y

Abstract excerpt

PURPOSE: The androgen receptor (AR) harbors a polymorphic CAG repeat sequence in exon 1, coding for a polyglutamine tract whose length inversely correlates with AR transactivation function. AIB1, an AR coactivator, expresses a similar polymorphic glutamine sequence within the carboxyl-terminal coding region. We hypothesized that genotypic variations in the androgen-signaling pathway promote aggressive epithelial...

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PMID: 16365010
DOI: 10.1158/1055-9965.EPI-05-0540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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Related research

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AIB1 polymorphisms predict aggressive ovarian cancer phenotype.PMID 16365010Read ↗

The AIB1 gene polyglutamine repeat length polymorphism contributes to risk of epithelial ovarian cancer risk: a case-control study.Semantic proximity Read ↗

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Breast cancer risk in BRCA1 and BRCA2 mutation carriers and polyglutamine repeat length in the AIB1 gene.Semantic proximity Read ↗

The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers.Semantic proximity Read ↗

The AIB1 glutamine repeat polymorphism is not associated with risk of breast cancer before age 40 years in Australian women.Semantic proximity Read ↗

Polyglutamine repeat length in the AIB1 gene modifies breast cancer susceptibility in BRCA1 carriers.Semantic proximity Read ↗

Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer.Semantic proximity Read ↗

Hyperandrogenism, mediated by obesity and receptor polymorphisms, promotes aggressive epithelial ovarian cancer biology.Semantic proximity Read ↗

AIB1 polymorphisms with breast cancer susceptibility: a pooled analysis of variation in BRCA1/2 mutation carriers and non-carriers.Semantic proximity Read ↗

The CAG repeats in exon 1 of the androgen receptor gene are significantly longer in endometrial cancer patients.Semantic proximity Read ↗

Modification of BRCA1-associated breast cancer risk by the polymorphic androgen-receptor CAG repeat.Semantic proximity Read ↗

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