Article
Short androgen receptor allele length is a poor prognostic factor in epithelial ovarian carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2003
Li Andrew J, Baldwin Rae Lynn, Karlan Beth Y
Abstract excerpt
PURPOSE: Epidemiological evidence implicates a heightened androgenic state in women with epithelial ovarian cancer. Androgen activity may be modulated by altered expression or activity of the androgen receptor (AR) or AR polymorphisms. Exon 1 of the AR gene contains a polymorphic (CAG)(n) sequence whose length is inversely correlated with transcriptional activity. EXPERIMENTAL DESIGN: Differential expression of...
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