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Article

Polyglutamine repeat length in the AIB1 gene modifies breast cancer susceptibility in BRCA1 carriers.

International journal of cancer - 20 Jan 2004

Kadouri Luna, Kote-Jarai Zsofia, Easton Douglas F, Hubert Ayala, Hamoudi Rifat, Glaser Benjamin, Abeliovich Dvorah, Peretz Tamar, Eeles Rosalind A

Abstract excerpt

Variation in the penetrance estimates for BRCA1 and BRCA2 mutation carriers suggests that other factors may modify cancer risk from specific mutations. One possible mechanism is an epigenetic effect of polymorphisms in other genes. Genes involved in hormonal signal transduction are possible candidates. The AIB1 gene, an estrogen receptor (ER) coactivator, is frequently amplified in breast and ovarian tumors....

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Source

Identifiers

PMID: 14648706
DOI: 10.1002/ijc.11531

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polyglutamine repeat length in the AIB1 gene modifies breast cancer susceptibility in BRCA1 carriers.PMID 14648706Read ↗

Breast cancer risk in BRCA1 and BRCA2 mutation carriers and polyglutamine repeat length in the AIB1 gene.Semantic proximity Read ↗

AIB1 polymorphisms with breast cancer susceptibility: a pooled analysis of variation in BRCA1/2 mutation carriers and non-carriers.Semantic proximity Read ↗

Polymorphic repeat length in the AIB1 gene and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a meta-analysis of observational studies.Semantic proximity Read ↗

The AIB1 gene polyglutamine repeat length polymorphism contributes to risk of epithelial ovarian cancer risk: a case-control study.Semantic proximity Read ↗

The AIB1 gene polyglutamine repeat length polymorphism and the risk of breast cancer development.Semantic proximity Read ↗

Modification of BRCA1- and BRCA2-associated breast cancer risk by AIB1 genotype and reproductive history.Semantic proximity Read ↗

The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers.Semantic proximity Read ↗

CAG and GGC repeat polymorphisms in the androgen receptor gene and breast cancer susceptibility in BRCA1/2 carriers and non-carriers.Semantic proximity Read ↗

The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers.Semantic proximity Read ↗

The AIB1 glutamine repeat polymorphism is not associated with risk of breast cancer before age 40 years in Australian women.Semantic proximity Read ↗

Somatic instability of the DNA sequences encoding the polymorphic polyglutamine tract of the AIB1 gene.Semantic proximity Read ↗

Polymorphic exonic CAG microsatellites in the gene amplified in breast cancer (AIB1 gene).Semantic proximity Read ↗

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