Breast cancer risk in BRCA1 and BRCA2 mutation carriers and polyglutamine repeat length in the AIB1 gene.

doi:10.1002/ijc.21176

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Article

Breast cancer risk in BRCA1 and BRCA2 mutation carriers and polyglutamine repeat length in the AIB1 gene.

International journal of cancer - 1 Nov 2005

Hughes David J, Ginolhac Sophie M, Coupier Isabelle, Barjhoux Laure, Gaborieau Valérie, Bressac-de-Paillerets Brigitte, Chompret Agnès, Bignon Yves-Jean, Uhrhammer Nancy, Lasset Christine, Giraud Sophie, Sobol Hagay, Hardouin Agnès, Berthet Pascaline, Peyrat Jean-Philippe, Fournier Joelle, Nogues Catherine, Lidereau Rosette, Muller Danièle, Fricker Jean-Pierre, Longy Michel, Toulas Christine, Guimbaud Rosine, Yannoukakos Drakoulis, Mazoyer Sylvie, Lynch Henry T, Lenoir Gilbert M, Goldgar David E, Stoppa-Lyonnet Dominique, Sinilnikova Olga M

Abstract excerpt

Marked variation in phenotypic expression among BRCA1 and BRCA2 mutation carriers may be partly explained by modifier genes that influence mutation penetrance. Variation in CAG/CAA repeat lengths coding for stretches of glutamines in the C-terminus of the AIB1 protein (amplified in breast cancer 1, a steroid receptor coactivator) has been proposed to modify the breast cancer risk in women carrying germline BRCA1...

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Identifiers

PMID: 15900600
DOI: 10.1002/ijc.21176

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Breast cancer risk in BRCA1 and BRCA2 mutation carriers and polyglutamine repeat length in the AIB1 gene.PMID 15900600Read ↗

Polyglutamine repeat length in the AIB1 gene modifies breast cancer susceptibility in BRCA1 carriers.Semantic proximity Read ↗

Polymorphic repeat length in the AIB1 gene and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a meta-analysis of observational studies.Semantic proximity Read ↗

The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers.Semantic proximity Read ↗

The AIB1 gene polyglutamine repeat length polymorphism and the risk of breast cancer development.Semantic proximity Read ↗

AIB1 polymorphisms with breast cancer susceptibility: a pooled analysis of variation in BRCA1/2 mutation carriers and non-carriers.Semantic proximity Read ↗

The AIB1 gene polyglutamine repeat length polymorphism contributes to risk of epithelial ovarian cancer risk: a case-control study.Semantic proximity Read ↗

The AIB1 glutamine repeat polymorphism is not associated with risk of breast cancer before age 40 years in Australian women.Semantic proximity Read ↗

Modification of BRCA1- and BRCA2-associated breast cancer risk by AIB1 genotype and reproductive history.Semantic proximity Read ↗

The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers.Semantic proximity Read ↗

Polymorphic repeat in AIB1 does not alter breast cancer risk.Semantic proximity Read ↗

Somatic instability of the DNA sequences encoding the polymorphic polyglutamine tract of the AIB1 gene.Semantic proximity Read ↗

AIB1 polymorphisms predict aggressive ovarian cancer phenotype.Semantic proximity Read ↗

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