Article
Modification of BRCA1-associated breast cancer risk by the polymorphic androgen-receptor CAG repeat.
American journal of human genetics - 1 May 1999
Rebbeck T R, Kantoff P W, Krithivas K, Neuhausen S, Blackwood M A, Godwin A K, Daly M B, Narod S A, Garber J E, Lynch H T, Weber B L, Brown M
Abstract excerpt
Compared with the general population, women who have inherited a germline mutation in the BRCA1 gene have a greatly increased risk of developing breast cancer. However, there is also substantial interindividual variability in the occurrence of breast cancer among BRCA1 mutation carriers. We hypothesize that other genes, particularly those involved in endocrine signaling, may modify the BRCA1-associated...
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