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Article

Identification of a basic surface area of the FADD death effector domain critical for apoptotic signaling.

FEBS letters - 11 Sept 2002

Kaufmann Markus, Bozic Damir, Briand Christophe, Bodmer Jean-Luc, Zerbe Oliver, Kohl Andreas, Tschopp Jürg, Grütter Markus G

Abstract excerpt

Death effector domains (DEDs) are protein-protein interaction domains found in the death inducing signaling complex (DISC). Performing a structure-based alignment of all DED sequences we identified a region of high diversity in alpha-helix 3 and propose a classification of DEDs into class I DEDs typically containing a stretch of basic residues in the alpha-helix 3 region whereas DEDs of class II do not....

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12220669
DOI: 10.1016/s0014-5793(02)03146-0

Genes

FADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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