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Article

Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function.

Journal of virology - 1 Jan 2002

Garvey Tara L, Bertin John, Siegel Richard M, Wang G H, Lenardo Michael J, Cohen Jeffrey I

Abstract excerpt

Molluscum contagiosum virus (MCV), a member of the human poxvirus family, encodes the MC159 protein that inhibits Fas-, tumor necrosis factor (TNF)-, and TNF-related apoptosis-inducing ligant (TRAIL)-induced apoptosis. We used site-directed mutagenesis to change charged or hydrophobic amino acid residues to alanines to identify regions of MC159 that are critical for protection from apoptosis and for...

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Identifiers

PMID: 11752160
DOI: 10.1128/jvi.76.2.697-706.2002
PMCID: PMC136828

Genes

FADD
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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