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Article

The crystal structure of human pyrin b30.2 domain: implications for mutations associated with familial Mediterranean fever.

Journal of molecular biology - 27 Nov 2009

Weinert Christopher, Grütter Christian, Roschitzki-Voser Heidi, Mittl Peer R E, Grütter Markus G

Abstract excerpt

The inherited autoinflammatory syndrome familial Mediterranean fever (FMF) is characterized by recurrent episodes of fever, which are independent of any bacterial or viral infections. This disease is associated with point mutations in the mefv gene product pyrin. Although the precise molecular functions of pyrin are unknown, it seems to be involved in the maturation and secretion of interleukin-1beta....

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Identifiers

PMID: 19729025
DOI: 10.1016/j.jmb.2009.08.059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The crystal structure of human pyrin b30.2 domain: implications for mutations associated with familial Mediterranean fever.PMID 19729025Read ↗

Complex formation dynamics of native and mutated pyrin's B30.2 domain with caspase-1.Semantic proximity Read ↗

[Influence of M680I and M694V mutations on pyrin's domain B30.2 tertiary structure and it's complex formation ability with caspase-1].Semantic proximity Read ↗

Mutations in the B30.2 and the Central Helical scaffold domains of pyrin differentially affect inflammasome activationSemantic proximity Read ↗

The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.Semantic proximity Read ↗

Mutations in the B30.2 and the central helical scaffold domains of pyrin differentially affect inflammasome activation.Semantic proximity Read ↗

Mutations in the B30.2 domain of pyrin and the risk of ankylosing spondylitis in the Chinese Han population: a case-control study.Semantic proximity Read ↗

The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment.Semantic proximity Read ↗

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A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean Fever.Semantic proximity Read ↗

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