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Article

A shuttle vector system for the investigation of immunoglobulin gene hypermutation: absence of enhanced mutability in intermediate B cell lines.

Molecular immunology - 1 Jan 2000

Johnston J M, Yu M T, Carroll W L

Abstract excerpt

Somatic hypermutation focused to the rearranged V(D)J segment of the immunoglobulin (Ig) loci contributes substantially to antibody gene diversification. However, neither the precise B cell subset subject to hypermutation nor the molecular mechanism(s) involved is known. One model proposes that Ig segments may be uniquely susceptible to DNA nicking and subsequent error-prone repair during a specific B cell...

Topics

Antibody Diversity
B-Lymphocytes
Cell Differentiation
Cells, Cultured
DNA Repair
Genes, Immunoglobulin
Genes, Suppressor
Genetic Vectors
Humans
Immunoglobulin Heavy Chains
In Vitro Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

RNA, Transfer, Tyr

Transfection

Source

Identifiers

PMID: 1635557
DOI: 10.1016/0161-5890(92)90140-s

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1635557-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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