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Article

The non-methylated DNA-binding function of Kaiso is not required in early Xenopus laevis development.

Development (Cambridge, England) - 1 Mar 2009

Ruzov Alexey, Savitskaya Ekaterina, Hackett Jamie A, Reddington James P, Prokhortchouk Anna, Madej Monika J, Chekanov Nikolai, Li Minghui, Dunican Donncha S, Prokhortchouk Egor, Pennings Sari, Meehan Richard R

Abstract excerpt

Mammalian forms of the transcription repressor, Kaiso, can reportedly bind methylated DNA and non-methylated CTGCNA motifs. Here we compare the DNA-binding properties of Kaiso from frog, fish and chicken and demonstrate that only the methyl-CpG-binding function of Kaiso is evolutionarily conserved. We present several independent experimental lines of evidence that the phenotypic abnormalities associated with...

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Identifiers

PMID: 19158185
DOI: 10.1242/dev.025569
PMCID: PMC2685941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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