Article

Kaiso (ZBTB33) engages with non-canonical binding motifs to regulate DNA damage responses in breast cancer cells

2025-11-07

Abstract excerpt

<title>Abstract</title> <p> In breast cancer, nuclear localization of Kaiso (ZBTB33), a dual specificity transcription factor, is a hallmark of high grade ductal-type carcinomas, especially in estrogen receptor negative disease. Regulation of gene expression by Kaiso is orchestrated via its engagement to distinct Kaiso binding sequence (KBS) motifs defined as canonical (cKBS; <italic>TCCTGCNA</italic> ) or CG-...

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Literature Corpus work: d2c757d4-04a6-5af5-855f-52eb316861a8
DOI: 10.21203/rs.3.rs-7846387/v1

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