Article
Comparative analysis of the NF2, TP53, PTEN, KRAS, NRAS and HRAS genes in sporadic and radiation-induced human meningiomas.
International journal of cancer - 15 Oct 2001
Joachim T, Ram Z, Rappaport Z H, Simon M, Schramm J, Wiestler O D, von Deimling A
Abstract excerpt
Irradiation to the head is associated with a significantly increased incidence of meningiomas. Radiation-induced meningiomas morphologically resemble their sporadically arising counterparts; however, they frequently exhibit a more malignant phenotype. Several genes have been shown to carry mutations in meningiomas, with the NF2 gene being most frequently affected. To examine whether the NF2 gene also plays a role...
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