Article
The BARD1 Cys557Ser variant and risk of familial breast cancer in a South-American population.
Molecular biology reports - 1 Aug 2012
Gonzalez-Hormazabal Patricio, Reyes Jose M, Blanco Rafael, Bravo Teresa, Carrera Ignacio, Peralta Octavio, Gomez Fernando, Waugh Enrique, Margarit Sonia, Ibañez Gladys, Santos Jose L, Jara Lilian
Abstract excerpt
Since the discovery of the BRCA1 and BRCA2 genes, much work has been carried out to identify further breast cancer (BC) susceptibility genes. BARD1 (BRCA1-associated ring domain) was originally identified as a BRCA1-interacting protein but has also been described in tumor-suppressive functions independent of BRCA1. Some association studies have suggested that the BARD1 Cys557Ser variant might be associated with...
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