Article
A genetic locus accentuates the effect of volume overload on adverse left ventricular remodeling in male and female rats.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 2006
Souzeau Emmanuelle, Llamas Bastien, Bélanger Sonia, Picard Sylvie, Deschepper Christian F
Abstract excerpt
Although increased left ventricular (LV) mass is highly predictive of cardiovascular morbidity and mortality in humans, it has never been verified in an experimental model that naturally occurring alleles linked to increased LV mass under basal conditions also associate with worsened cardiovascular prognosis. Because we have shown previously that locus Cm24 on chromosome 5 was responsible for differences in LV...
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