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Article

Transcriptional regulation of the Drosophila orc2 gene by the DREF pathway.

Biochimica et biophysica acta - 30 Dec 2005

Okudaira Koji, Ohno Katsuhito, Yoshida Hideki, Asano Maki, Hirose Fumiko, Yamaguchi Masamitsu

Abstract excerpt

DNA replication-related element (DRE) and the DRE-binding factor (DREF) play an important role in regulating DNA replication-related genes such as PCNA and DNA polymerase alpha in Drosophila. We have previously reported that overexpression of DREF in developing eye imaginal discs induced ectopic DNA synthesis and apoptosis, which results in rough eyes. To identify genetic interactants with the DREF gene, we have...

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Source

Identifiers

PMID: 16343659
DOI: 10.1016/j.bbaexp.2005.10.009

Genes

PCNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Transcriptional regulation of the Drosophila orc2 gene by the DREF pathway.PMID 16343659Read ↗

Transcriptional regulation of the Drosophila rfc1 gene by the DRE-DREF pathway.Semantic proximity Read ↗

Identification of the Drosophila eIF4A gene as a target of the DREF transcription factor.Semantic proximity Read ↗

Ectopic expression of DREF induces DNA synthesis, apoptosis, and unusual morphogenesis in the Drosophila eye imaginal disc: possible interaction with Polycomb and trithorax group proteins.Semantic proximity Read ↗

Genetic screening for modifiers of the DREF pathway in Drosophila melanogaster: identification and characterization of HP6 as a novel target of DREF.Semantic proximity Read ↗

Transcriptional regulation of the Drosophila moira and osa genes by the DREF pathway.Semantic proximity Read ↗

Role of DREF in transcriptional regulation of the Drosophila p53 gene.Semantic proximity Read ↗

Drosophila distal-less negatively regulates dDREF by inhibiting its DNA binding activity.Semantic proximity Read ↗

Drosophila Mi-2 negatively regulates dDREF by inhibiting its DNA-binding activity.Semantic proximity Read ↗

DREF is required for efficient growth and cell cycle progression in Drosophila imaginal discs.Semantic proximity Read ↗

Functional analysis of an Orc6 mutant in Drosophila.Semantic proximity Read ↗

Dynamic changes in the genomic localization of DNA replication-related element binding factor during the cell cycle.Semantic proximity Read ↗

Transcription control of a gene for Drosophila transcription factor, DREF by DRE and cis-elements conserved between Drosophila melanogaster and virilis.Semantic proximity Read ↗

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