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Article

Genetic screening for modifiers of the DREF pathway in Drosophila melanogaster: identification and characterization of HP6 as a novel target of DREF.

Nucleic acids research - 1 Apr 2009

Ida Hiroyuki, Suzusho Noriyuki, Suyari Osamu, Yoshida Hideki, Ohno Katsuhito, Hirose Fumiko, Itoh Masanobu, Yamaguchi Masamitsu

Abstract excerpt

The DNA replication-related element-binding factor (DREF) regulates cell proliferation-related gene expression in Drosophila. By genetic screening, taking advantage of the rough eye phenotype of transgenic flies that express DREF in the eye discs, we identified 24 genes that suppressed and 12 genes that enhanced the rough eye phenotype when heterozygous for mutations. Five genes, HP6, pigeon, lace, X box binding...

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Identifiers

PMID: 19136464
DOI: 10.1093/nar/gkn1068
PMCID: PMC2655671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic screening for modifiers of the DREF pathway in Drosophila melanogaster: identification and characterization of HP6 as a novel target of DREF.PMID 19136464Read ↗

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