XAF1 nonsense mutation rs117407731 enhances lung adenocarcinoma susceptibility via apoptosis suppression.

doi:10.1007/s00438-026-02421-3

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Article

XAF1 nonsense mutation rs117407731 enhances lung adenocarcinoma susceptibility via apoptosis suppression.

Molecular genetics and genomics : MGG - 24 Apr 2026

Xu Guanxin, Zhang Hang, Zhang Sai, Yu Danqing

Abstract excerpt

Lung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer, the leading cause of global cancer-related mortality. Genetic mutations play critical roles in LUAD pathogenesis. This study aims to investigate the role of XIAP-associated factor 1 (XAF1) rs117407731, a nonsense mutation in certain splice variants (p.22W>*, TGG to TGA), in LUAD susceptibility and cellular function. Genotyping of XAF1...

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PMID: 42029946
DOI: 10.1007/s00438-026-02421-3

Genes

XAF1
XIAP

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