Article
Identification of a Germline XAF1 Mutation in Patients With Gastrointestinal Cancers.
Human mutation - 1 Jan 2026
Xu Guan-Xin, Zhang Hang, Wang Chang-Xing, Zhang Ying-Zhi, Lv Ping-Ping, Feng Chun, Ning Yao, Shen Miao, Zhang Sai, Jin Min, Yu Dan-Qing
Abstract excerpt
Background: Gastrointestinal (GI) cancers can be attributed to the interplay between genetic and environmental factors. To date, apart from certain cancer syndromes, the genetic factors underlying familial GI cancers have not been clearly elucidated. Methods: Blood samples were collected from six members of a family with GI cancer for whole exome sequencing to identify suspicious germline mutations. Subsequently,...
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