Promoter hypermethylation of <i>p15</i>^{<i>INK</i>4<i>B</i>}, <i>HIC1</i>, <i>CDH1</i>, and <i>ER</i> is frequent in myelodysplastic syndrome and predicts poor prognosis in early‐stage patients

Abstract excerpt

The propensity of myelodysplastic syndrome (MDS) to transform into acute myeloid leukemia (AML) suggests the existence of common pathogenic components for these malignancies. Here, four genes implicated in the development of AML were examined for promoter CpG island hypermethylation in cells from 37 patients with different stages of MDS. Aberrant methylation was detected by polymerase chain reaction amplification...

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