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Article

Hypermethylation of the p15INK4B Gene in Myelodysplastic Syndromes

15 Aug 1997

Abstract excerpt

Previous studies have shown that the cyclin-dependent kinase inhibitor (CDKI) genes p15INK4B and p16INK4A are frequently inactivated by genetic alterations in many malignant tumors and that they are candidate tumor-suppressor genes. Although genetic alterations in these genes may be limited to lymphoid malignancies, it has been reported that their inactivation by aberrant methylation of 5' CpG islands may be...

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PMID: 9269757
DOI: 10.1182/blood.v90.4.1403

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