Article
IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis.
Haematologica - 1 Oct 2010
Thol Felicitas, Weissinger Eva M, Krauter Jürgen, Wagner Katharina, Damm Frederik, Wichmann Martin, Göhring Gudrun, Schumann Christiane, Bug Gesine, Ottmann Oliver, Hofmann Wolf-Karsten, Schlegelberger Brigitte, Ganser Arnold, Heuser Michael
Abstract excerpt
BACKGROUND: Myelodysplastic syndromes are a heterogeneous group of hematopoietic stem cell disorders with a high propensity to transform into acute myeloid leukemia. Heterozygous missense mutations in IDH1 at position R132 and in IDH2 at positions R140 and R172 have recently been reported in acute myeloid leukemia. However, little is known about the incidence and prognostic impact of IDH1 and IDH2 mutations in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.