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Article

Gene silencing by DNA methylation in haematological malignancies

9 May 2007

Abstract excerpt

The past decade has seen an explosion of interest in the epigenetics of cancer, with an increasing understanding that this form of genomic modification plays a critical role in pathogenesis. The malignant phenotype results from a step-wise increase of both genetic abnormalities and epigenetic modifications, leading to dysregulation of critical genes controlling cell growth, differentiation and apoptosis. The...

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PMID: 17489980
DOI: 10.1111/j.1365-2141.2007.06604.x

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