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Article

Functional and genetic analysis of coronavirus replicase-transcriptase proteins.

PLoS pathogens - 1 Dec 2005

Sawicki Stanley G, Sawicki Dorothea L, Younker Diane, Meyer Yvonne, Thiel Volker, Stokes Helen, Siddell Stuart G

Abstract excerpt

The coronavirus replicase-transcriptase complex is an assembly of viral and cellular proteins that mediate the synthesis of genome and subgenome-sized mRNAs in the virus-infected cell. Here, we report a genetic and functional analysis of 19 temperature-sensitive (ts) mutants of Murine hepatitis virus MHV-A59 that are unable to synthesize viral RNA when the infection is initiated and maintained at the...

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Identifiers

PMID: 16341254
DOI: 10.1371/journal.ppat.0010039
PMCID: PMC1298938

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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