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Article

Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis.

Journal of virology - 1 Jun 2007

Donaldson Eric F, Sims Amy C, Graham Rachel L, Denison Mark R, Baric Ralph S

Abstract excerpt

Coronavirus replication requires proteolytic processing of the large polyprotein encoded by ORF1a/ab into putative functional intermediates and eventually approximately 15 mature proteins. The C-terminal ORF1a protein nsp10 colocalizes with viral replication complexes, but its role in transcription/replication is not well defined. To investigate the role of nsp10 in coronavirus transcription/replication, alanine...

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Identifiers

PMID: 17392363
DOI: 10.1128/JVI.02805-06
PMCID: PMC1900072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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