Article
Establishing a genetic recombination map for murine coronavirus strain A59 complementation groups.
Virology - 1 Aug 1990
Baric R S, Fu K, Schaad M C, Stohlman S A
Abstract excerpt
MHV-A59 temperature-sensitive mutants, representing one RNA+ and five RNA- complementation groups, were isolated and characterized by genetic recombination techniques. Maximum recombination frequencies occurred under multiplicities of infection greater than 10 each in which 99.99% of the cells were co-infected. Recombination frequencies between different ts mutants increased steadily during infection and peaked...
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