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Article

Induction of apoptosis and activation of NF-kappaB by CD95 require different signalling thresholds.

EMBO reports - 1 Nov 2004

Legembre Patrick, Barnhart Bryan C, Zheng Lixin, Vijayan Shrijay, Straus Stephen E, Puck Jennifer, Dale Janet K, Lenardo Michael, Peter Marcus E

Abstract excerpt

Mutations in the death domain of the death receptor CD95 (APO-1/Fas) cause lymphoproliferation and autoimmune disease in both lpr(cg) mice and in patients with autoimmune lymphoproliferative syndrome (ALPS) type Ia. By testing lymphocytes from ALPS type Ia patients, comparing heterozygous with ho...

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Identifiers

PMID: 15514680
DOI: 10.1038/sj.embor.7400280
PMCID: PMC1299175

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15514680-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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