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Article

Alzheimer's protective A2T mutation changes the conformational landscape of the Aβ₁₋₄₂ monomer differently than does the A2V mutation.

Biophysical journal - 3 Feb 2015

Das Payel, Murray Brian, Belfort Georges

Abstract excerpt

The aggregation of amyloid-β (Aβ) peptides plays a crucial role in the etiology of Alzheimer's disease (AD). Recently, it has been reported that an A2T mutation in Aβ can protect against AD. Interestingly, a nonpolar A2V mutation also has been found to offer protection against AD in the heterozygous state, although it causes early-onset AD in homozygous carriers. Since the conformational landscape of the Aβ...

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Identifiers

PMID: 25650940
DOI: 10.1016/j.bpj.2014.12.013
PMCID: PMC4317528

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