Article
Increased frequency of TP53 mutations in BRCA1 and BRCA2 ovarian tumours.
Genes, chromosomes & cancer - 1 Jun 1999
Ramus S J, Bobrow L G, Pharoah P D, Finnigan D S, Fishman A, Altaras M, Harrington P A, Gayther S A, Ponder B A, Friedman L S
Abstract excerpt
We screened 81 ovarian tumours (30 BRCA1 associated, 18 BRCA2 associated, and 33 sporadic) for somatic TP53 mutations using both DNA analysis and immunostaining. TP53 mutations were significantly more frequent in tumours with mutations in BRCA1 (70% by immunostaining and 60% by DNA analysis) and BRCA2 (67% and 50%) compared to sporadic controls (39% and 30%) (P = 0.009). A higher proportion of tumours with BRCA1...
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