Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation analysis of the HIF-1alpha oxygen-dependent degradation domain in invasive breast cancer.

Cancer genetics and cytogenetics - 1 Dec 2005

Vleugel Marije M, Greijer Astrid E, van der Wall Elsken, van Diest Paul J

Abstract excerpt

Hypoxia inducible factor-1 (HIF-1) is an important transcription factor that stimulates tumor growth and metastases via several pathways. Activation of HIF-1 depends on the presence of its alpha-subunit. Hypoxia increases HIF-1alpha levels by inhibiting prolyl-hydroxylase--mediated hydroxylation and thereby preventing proteosome degradation. Various other mechanisms might also contribute to HIF-1alpha expression,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Breast Neoplasms
Share to DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Immunohistochemistry

Share to Neoplasm Invasiveness

Share to Oxygen

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 16337862
DOI: 10.1016/j.cancergencyto.2005.05.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Mutation analysis of the HIF-1alpha oxygen-dependent degradation domain in invasive breast cancer.PMID 16337862Read ↗

Identification of hypoxia-inducible factor-1alpha (HIF-1alpha) polymorphism as a mutation in prostate cancer that prevents normoxia-induced degradation.Semantic proximity Read ↗

Human hormone-refractory prostate cancers can harbor mutations in the O(2)-dependent degradation domain of hypoxia inducible factor-1alpha (HIF-1alpha).Semantic proximity Read ↗

Rare variant of hypoxia-inducible factor-1alpha (HIF-1A) and breast cancer risk in Korean women.Semantic proximity Read ↗

Molecular evolution of the metazoan PHD-HIF oxygen-sensing system.Semantic proximity Read ↗

BRCA1 tumours correlate with a HIF-1alpha phenotype and have a poor prognosis through modulation of hydroxylase enzyme profile expression.Semantic proximity Read ↗

Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer.Semantic proximity Read ↗

Proline-Hydroxylated Hypoxia-Inducible Factor 1α (HIF-1α) Upregulation in Human TumoursSemantic proximity Read ↗

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha.Semantic proximity Read ↗

HIF-1α Hydroxyprolines Modulate Oxygen-Dependent Protein Stability Via Single VHL Interface With Comparable Effect on Ubiquitination Rate.Semantic proximity Read ↗

High frequency of HIF-1alpha overexpression in BRCA1 related breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.