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Article

Human hormone-refractory prostate cancers can harbor mutations in the O(2)-dependent degradation domain of hypoxia inducible factor-1alpha (HIF-1alpha).

Journal of cancer research and clinical oncology - 1 Jul 2002

Anastasiadis Aristotelis G, Ghafar Mohamed A, Salomon Laurent, Vacherot Francis, Benedit Patricia, Chen Min-Wei, Shabsigh Ahmad, Burchardt Martin, Chopin Dominique K, Shabsigh Ridwan, Buttyan Ralph

Abstract excerpt

PURPOSE: Androgen ablation, the preferred therapy for advanced prostate cancer, reduces blood flow and induces hypoxia in androgen-dependent tissues. Given the transient effectiveness of this therapy, we must consider whether a hypoxia-resistance mechanism might be involved in the development of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12136249
DOI: 10.1007/s00432-002-0346-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12136249-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Human hormone-refractory prostate cancers can harbor mutations in the O(2)-dependent degradation domain of hypoxia inducible factor-1alpha (HIF-1alpha).PMID 12136249Read ↗

Identification of hypoxia-inducible factor-1alpha (HIF-1alpha) polymorphism as a mutation in prostate cancer that prevents normoxia-induced degradation.Semantic proximity Read ↗

The homozygous P582S mutation in the oxygen-dependent degradation domain of HIF-1 alpha is associated with increased risk for prostate cancer.Semantic proximity Read ↗

Hypoxia-inducible factor-1 in human breast and prostate cancerSemantic proximity Read ↗

Hypoxia-Inducible Factor 1α and 1β Proteins Share Common Signaling Pathways in Human Prostate Cancer CellsSemantic proximity Read ↗

Mutation analysis of the HIF-1alpha oxygen-dependent degradation domain in invasive breast cancer.Semantic proximity Read ↗

Hormone Therapy Failure in Human Prostate Cancer: Analysis by Complementary DNA and Tissue MicroarraysSemantic proximity Read ↗

The HIF1A functional genetic polymorphism at locus +1772 associates with progression to metastatic prostate cancer and refractoriness to hormonal castration.Semantic proximity Read ↗

Analysis of hypoxia-associated gene expression in prostate cancer: lysyl oxidase and glucose transporter-1 expression correlate with Gleason scoreSemantic proximity Read ↗

Polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to androgen-independent prostate cancer.Semantic proximity Read ↗

Hypoxia-associated p38 mitogen-activated protein kinase-mediated androgen receptor activation and increased HIF-1alpha levels contribute to emergence of an aggressive phenotype in prostate cancer.Semantic proximity Read ↗

Chronic hypoxia promotes an aggressive phenotype in rat prostate cancer cellsSemantic proximity Read ↗

HIF1A C1772T polymorphism leads to HIF-1α mRNA overexpression in prostate cancer patients.Semantic proximity Read ↗

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