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Article

Presenilin mouse and zebrafish models for dementia: focus on neurogenesis.

Progress in neurobiology - 1 Feb 2011

van Tijn Paula, Kamphuis Willem, Marlatt Michael W, Hol Elly M, Lucassen Paul J

Abstract excerpt

Autosomal dominant mutations in the presenilin gene PSEN cause familial Alzheimer's disease (AD), a neurological disorder pathologically characterized by intraneuronal accumulation and extracellular deposition of amyloid-β in plaques and intraneuronal, hyperphosphorylated tau aggregation in neurofibrillary tangles. Presenilins (PS/PSENs) are part of the proteolytic γ-secretase complex, which cleaves substrate...

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Identifiers

PMID: 21056616
DOI: 10.1016/j.pneurobio.2010.10.008

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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