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Article

Hypoxia Is a Critical Parameter for Chondrogenic Differentiation of Human Umbilical Cord Blood Mesenchymal Stem Cells in Type I/III Collagen Sponges.

International journal of molecular sciences - 8 Sept 2017

Gómez-Leduc Tangni, Desancé Mélanie, Hervieu Magalie, Legendre Florence, Ollitrault David, de Vienne Claire, Herlicoviez Michel, Galéra Philippe, Demoor Magali

Abstract excerpt

Umbilical cord blood (UCB) is an attractive alternative to bone marrow for isolation of mesenchymal stem cells (MSCs) to treat articular cartilage defects. Here, we set out to determine the growth factors (bone morphogenetic protein 2 (BMP-2) and transforming growth factor-β (TGF-β1)) and oxygen tension effects during chondrogenesis of human UCB-MSCs for cartilage engineering. Chondrogenic differentiation was...

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Topics

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Share to Bone Morphogenetic Protein 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Collagen Type I

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Source

Open in PubMed Open full text

Identifiers

PMID: 28885597
DOI: 10.3390/ijms18091933
PMCID: PMC5618582

Genes

MMP13
MSC
UBC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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